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Consensus Opinion: the role of calcium in peri-and postmenopausal women: consensus opinion of The North American Menopause Society.

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Being treated with a bisphosphonate medication such as zoledronic acid injection for osteoporosis may increase the risk that you will break your thigh bone(s).

In addition, patients with other medical problems that can cause electrolyte imbalances or patients with kidney disease may need their dose of bisphosphate medication adjusted.

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Laboratory Test Findings: Throughout the Phase 3 studies, transient decreases from baseline in serum calcium (less than 1%) and serum phosphate (less than 3%) and compensatory increases in serum PTH levels (less than 30%) were observed within 6 months in patients in osteoporosis clinical trials treated with Actonel 5 mg once daily.

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Health Initiative Memory Study (WHIMS) released more results in May 2003.

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