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Tumor Necrosis Factor-α Monoclonal Antibodies in the Treatment of Inflammatory Bowel Disease: Clinical Practice Pharmacology.

Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease.

Physicians using it should be familiar with this risk and with possible hematologic toxicities and mutagenic potential in both sexes.

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Patients were evaluated at diagnosis, at randomization, every 2 months thereafter for 1 year, and then every 6 months until the end of the study, when the last patient included in the study discontinued maintenance therapy.

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Long-term immunosuppressive treatment does not efficiently prevent relapses of lupus nephritis (LN).

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