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Although cholesterol makes up only 5% of bile, about three-fourths of the gallstones found in the US population are formed from cholesterol.

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Analysis of 22 patients given clofibrate for 2-5 years, no changes in serum enzymes; one patient had rise in BSP clearance without other abnormalities).

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There was no statistically significant effect of multiple doses of fenofibrate on glucose nadir or AUC with the baseline glucose concentration as the covariate after glimepiride administration in healthy volunteers.

Although fenofibrate decreases the levels of fatty substances in the blood, it has not been shown to decrease the risk of heart problems that may be caused by these substances.

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That point was seconded by Lona Sandon, program director of the department of clinical nutrition at UT Southwestern, at Dallas.

Men who have their gallbladder removed are more likely to have severe disease and surgical complications than women.

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Concomitant administration of fenofibrate (equivalent to fenofibrate 200 mg) with atorvastatin (20 mg) once daily for 10 days resulted in approximately 17% decrease (range from 67% decrease to 44% increase) in atorvastatin AUC values in 22 healthy males.

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Consider screening those with type 1 diabetes for other autoimmune diseases (thyroid, vitamin B 12 deficiency, celiac) as appropriate.

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