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Those treated with methotrexate alone (24 of the patients) were just as likely to be in remission after three months as those who took methotrexate together with an infliximab (Remicaid) induction regimen (27 patients) and those who took methotrexate in conjunction with prednisolone (a steroid) (12 patients).

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The rate of hydrolysis of budesonide-beta- d-glucuronide in human faecal samples from patients with ulcerative colitis and normal volunteers is similar but it is unclear if a reduction in pH in the colon in patients with IBD may inhibit bacterial deconjugation of the prodrug.

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