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FDA Drug Safety Communication: FDA investigating reports of possible increased risk of pancreatitis and pre-cancerous findings of the pancreas from incretin mimetic drugs for type 2 diabetes.

Instruct patient to immediately discontinue drug and report if signs and symptoms of pancreatitis occur (persistent severe abdominal pain, sometimes radiating to the back, which may or may not be accompanied by vomiting).

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Be sure to mention any of the following: digoxin (Lanoxicaps, Lanoxin); insulin; and certain oral medications for diabetes including acetohexamide, chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol, in Metaglip), glyburide (Diabeta, Glycron, Micronase), tolazamide (Tolinase), and tolbutamide.

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Metformin hydrochloride ( N, N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents.

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Sitagliptin, the first in a new class of diabetic drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors, is approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

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Januvia slows the inactivation of incretin hormones and thus increases and prolongs their action.

The 200 mg daily dose did not provide greater glycemic efficacy than the 100 mg daily dose in either trial.

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Like any other medication this drug should also be taken under the strict supervision of the doctor and the patient has to strictly adhere to the treatment modality and also to the timings of the prescribed dose.

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NOT make decisions about your medication regimen, and to see an Endocrinologist for control of your diabetes, or you may suffer consequences!

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Saxagliptin is indicated for patients with type 2 diabetes mellitus to improve glycemic control in combination with metformin, a sulfonylurea, metformin and a sulfonylurea, or long- or intermediate-acting insulin (with or without metformin), when these drugs do not provide adequate glycemic control.

If you have any questions or problems, you should talk to your doctor or other healthcare provider about type 2 diabetes as well as GLUCOVANCE (glyburide and metformin) and its side effects.

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