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How long does savella stay in your system? Half-Life Of Savella (Milnacipran) Savella has a half-life of approximately 8 hours, which involves a much quicker elimination of the drug than other antidepressants. This means that 8 hours after taking a 10-mg dose of Savella, the presence of medication in a person's body would be reduced to 5 mg.
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